The Goal of Basic Science Research

Basic science research is scientific study designed to gain a fundamental understanding of the subject under investigation. In SCI research, basic science strives to answer questions about changes in:

1. the anatomy (structure of the nervous system),

2. the physiology (the functions and activities of cells in the nervous system), and

3. the cells, molecules, and genes within the nervous system.

Another function of basic science research is to develop and test the effectiveness of potential treatments. This is usually carried out in non-human models of SCI. Once compelling basic science evidence is obtained, researchers then strive to move the findings into clinical studies in humans.

The problem of central nervous system (CNS) injury is incredibly complex. The search for effective treatments is a long scientific process requiring extensive studies in critical basic science and clinical issues. Many scientists believe that significant new treatments will not be found in a single approach but, rather, in a combination of techniques. Therefore, it is important that all promising approaches be addressed in our search for a cure for SCI.

The Miami Project has assembled a research team with a broad spectrum of basic science expertise. This team works together to learn more about the spinal cord's response to injury and to develop strategies to promote spinal cord repair.

The Miami Project's basic science effort consists of simultaneous studies in the following important areas:

• Understanding injury mechanisms and protecting the spinal cord (pathophysiology, neuroprotection)

• Replacing lost nerves (cell replacement) or neurotransmitters (transmitter replacement)

• Promoting repair of damaged nerve pathways (regeneration)

• Understanding and restoring spinal connections and addressing issues of pain and spasticity (neurophysiology)

The Search for a Cure
When will basic science research lead to a cure? Since SCI affects many different bodily systems, it is likely that therapeutic strategies will need to be multifaceted and focused on specific problems. Because of advances in SCI research over the last decade, scientists are optimistic that new strategies can be developed to promote return of function and improvements in quality of life. Miami Project researchers, together with scientific colleagues around the world, are designing studies to answer relevant scientific questions to lead to the discovery of new treatments for SCI.

For an overview of the progress in the various areas of The Miami Project's basic science research, follow the links on the left.