The Miami Project faculty is comprised of a multidisciplinary team of both basic and clinical scientists with expertise in neuroscience.
Message from the Scientific Director, W. Dalton Dietrich, Ph.D.
The Miami Project to Cure Paralysis, at the University of Miami Miller School of Medicine has received clearance from the U.S. Food and Drug Administration (FDA) to proceed with a Phase I clinical trial to evaluate the safety of autologous human Schwann cell transplantation in the chronic spinal cord injury (SCI) setting.
The clinical protocol of the Phase I trial is focused on safety and feasibility outcomes. The investigative team is already conducting a Phase I trial assessing safety of autologous Schwann cell transplantation in individuals with subacute SCI. The new trial will be conducted in parallel and focus on individuals with chronic SCI. Individuals that are at least 1 year post-injury will have to meet the inclusion/exclusion criteria and agree to participate in the trial, which initially will require approximately 10 months of their time.
Participants will be monitored long-term for a total of five years. Each participant’s own Schwann cells will be obtained from a sural nerve biopsy. The Schwann cells will then need to be derived from the nerve and processed in a culturing facility to generate the number of cells necessary for transplantation, and to undergo a purification process. The cell therapy will be combined with an intense exercise and rehabilitation intervention to maximize outcome.
Led by W. Dalton Dietrich, Ph.D., Scientific Director, The Miami Project to Cure Paralysis, the Schwann cell clinical trial team is comprised of a multi-disciplinary group of faculty level scientists, neurosurgeons, and staff focused on advancing the trial.
The Clinical Trials Initiative is The Miami Project’s efforts to carefully take new discoveries from the laboratory to test as treatments in clinical trials. With a special emphasis on spinal cord injury, the Clinical Trials Initiative was started in 2004 and is aimed at creating the infrastructure needed to gain approval for and to conduct clinical trials at the University of Miami affiliated hospitals. Two treatments we are currently testing under this clinical trials initiative are Schwann cell transplantation and therapeutic hypothermia. We anticipate these activities will bring new and potentially life-changing treatments to people with central nervous system trauma.
Our broad scope of collaborative research is dedicated to finding new treatments for spinal cord injury.
Message from the Chairman, Barth A. Green, M.D.
September 1, 2015 – U.S. Senate Resolution 235, introduced by Florida Senators' Bill Nelson and Marco Rubio, designates September 2015 as “National Spinal Cord Injury Awareness Month”. This designation is especially timely given the significant progress being made toward a cure for spinal cord injury at The Miami Project to Cure Paralysis at the University of Miami Miller School of Medicine.
Go to your social media accounts and let people know that September is National SCI Awareness Month. Post a video about why finding a cure for paralysis is important to you. Share your video or link with us at firstname.lastname@example.org and we will post them on our Facebook page. Feel free to save these images and share with your friends.
March 18th of this year marked the seventeen year anniversary of the automobile accident that left me paralyzed from the neck down. Seventeen years is quite a long time and I believe by now I have living with a spinal cord injury down to a science. Full Story
The Miami Project has many ongoing clinical trials for spinal cord and brain injury.
If you are interested in participating in our clinical trials, complete our intake form today.